22"s aren't all that easy to pull it's not just weight but more mass overall and it changes end gear ratio... I don't know about the stock gearing but I'd wager stock gearing 22"s would be hard for a blaster to pull to powerband in 6th on anything but a downhill... doesn't mater what you weight the tires are rotational mass.. I weight 125 and my 450 had a huge power loss when I went with heavy chrome rims and 20" rear XCRs I had to regear and my 450 has cherry bomb and heavy intake mods and an 08 exhaust with no spark arrestor which is about 1.5whp over stock 06-07 and the spark arrestor removal gains a bit too. so I'm about 7+ whp over stock and still had a hard time pulling the heavy rims w/20"s... I had to regear, I dropped a tooth up front and added two out back and it has more pull then before the tires... less top speed tho.
my 660 had a noticeable power drop in moving to 22"s as well. it has alot of torque so it pulls them, but I could definitely tell it was less peppy as well. I intend to regear but it still wheelie's so not that big of a deal with the displacement I have apparently..
2 strokes it's even worse, you only have real power in the power band... if you can't get there it's a dead give away for me to drop a tooth in front...
tuning does hurt when running rich, but I'm not so sure if even prime running it'd help pull 6th into the power band with stock gearing on 22"s... at least not uphill.. I like my bikes to be able to pull where ever. not just on flats. I'm willing to sacrifice top speed for power. off road do you really need street bike speed? and street bikes are PLENTY safer on the streets at speed and quads unless asphalt ready don't belong racing on the pavement imo... even in dunes, you want speed but you still want power to be able to pull up hills from what I can imagine...
check jetting but don't be afraid to regear if needed
you could always try a quick raise in the needle as well if you don't have jets or can't get one right away. I move my needle position on my kids LT80 to do small jet changes. it was actually running rich (bottom clip) and would miss in mid rpm so I raised it to middle and it would rev up good. then I raised it another notch and it revs better and has almost instant power again (recently rebuilt it and was playing with it previously because of problems so had to retune) my raptor was running rich too but like I said, displacement and plenty of tq have it spinning the 22"s without much problems... my bikes are also all lightly modded for more power.