Yeppers I have 2 sets of 22" tires.
You'll be OK if you listen to the above advice.
My only complaint is the 22" Razr's sit a lil tall compared to other 22" tires.
my 22's fit ok, but i don't have heel guards (yet). I went with 18's on mine now though. the 22's are good for trails and stuff but not so much for mx type stuff