Its generally known you wont really have to touch the pilot, just the main and possibly the needle.
Stock main jet is a ~230 I think. With a Toomey youre looking at a ~280-310 realm. It really depends on where you live too.
I cant take jetting advice from these guys on here, cause I live at a higher altitude than most of them combined LOL. Im riding at ~8000 feet on average. Sometimes around 5500-6500, sometimes at 9000-10000 so my jetting will be far leaner than someone who lives at sea level to 2000 feet.
But yeah, the pipe install is easy. Positioning it can be a pain, but it isnt too hard. You shouldnt have any problems replacing the actual pipe itself. The hard part is rejetting the carb, which isnt much of a problem either. Im sure theres plenty of threads on here talking about Toomey B1 jetting on a stock carb to get you a good ballpark figure.
I dont even own a Toomey or a stock carb, but Ive read enough about them in various jetting threads, Im pretty sure my jetting ballpark is pretty close.
Dont take my word for it without searching yourself though thats for sure.