Do you mean the Boyesen "RAD" valve ? If you mean the aftermarket RAD valve and not just Boyesen reeds then yes, you may need to adjust your jetting. Usually changing reeds doesn't require jetting changes but 2x out of 3 I had to re jet with the Boyesen RAD valve. I actually went down on the main << sounds odd I know but that's what the plug chop said. Both instances i only dropped one size and one was with an Fmf and the other was with a right bend pipe (Ct, power pros,f7, etc...)..
You should plug chop to confirm your jetting though since every motor/combination is different.. What
are all of your mods now and what is current jetting ?