Acetone and toluene are not suitable octane boosters in great quantity. As gridlock stated "in the correct amounts" (which is low) they can raise the octane rating but they both have downsides...
Acetone does not delay the onset of precombustion as it's autoignition temperature is ~ 850 degrees F. What it does do is draw off more latent heat as it evaporates cooling the overall mixture down significantly to the point it inhibits precombustion slightly. But, it also produces acetone peroxide in small quantities as it oxidizes. Acetone peroxide is extremely shock sensitive and will initiate precombustion. Also, the fuel only has three carbon atoms per molecule so it's relatively light on energy.
Toluene is a good octane booster BUT the chemical does not have the lubricity that gasoline does. It causes an extraordinary amount of top end wear and because of it's reactive nature you have to use special rubber in the fuel system. It will eat the float needle tip and the crank seal lips causing problems later on. Also, you have to heat the fuel significantly before it will ignite. Because the fuel is used on the blaster engine as a significant source of cooling, I doubt the toluene component of the fuel mixture will reach the required 160 degrees F before the moment of spark timing meaning that it actually changes WHEN your engine is timed. The resulting late explosion would rush down the tuned pipe. That may help scavenging and it may not but I can tell you it will change the tune of your engine. The good news is, toluene has seven carbon atoms in it's molecule which means it's relatively energy dense.
If you don't mind searching for the proper float needle tip, you could find a service station that sells E85. It's 85% ethanol and 15% gasoline. It's octane rating is ~109. It, like the others in this post, eats organic rubber (but not as much as toluene) so the float tip has to be special but it can be bought by the gallon much cheaper than paint thinner. Unfortunately, it's relatively energy poor. Ethanol only has two carbon atoms so mixing too much of it with gasoline raises the octane rating but hurts energy density (which is why E85 powered vehicles get about 80% of the fuel economy that gasoline powered vehicles get).
Now, if you don't mind setting up a mixing station you can blend your own custom fuel out of a combination of the chemicals to take advantage of each's characteristics while keeping under the limit for damage from any one chemical. Start with 93 octane pump gas. Mix in 20% ethanol by volume, 8% acetone, and 15% toluene. You'll end up with almost twice as much fuel as you started with and several octane points higher.
Remember, if you do try an exotic blend of fuels, you'll have to rejet. Most of them are carbon poor and hydrogen rich. They evaporate cooler but burn hotter than gasoline, you must run more fuel than straight gasoline.
Now, after the chemisty lesson, back to the post. You generally do not change the pre-mix ratio for engine modifcations. The pre-mix ratio is set because it is independent of the amount of fuel needed for proper combustion. As soon as the fuel passes into the crankcase, the fuel atomizes but the oil doesn't. The oil spurts into the crankcase as whole droplets while the fuel is sucked up into the transfers with the air. Once you determine how much oil your engine needs to stay in one piece you don't vary the ratio to get more or less oil. You change jetting to affect how much fuel is allowed to mix with the incoming air to change the burn characteristics, the oil is just along for the ride.